Semaglutide vial quality red flags — what a proper COA should actually show

Semaglutide is one of the most counterfeited/misrepresented compounds in this space right now, precisely because demand is so high. A few quality issues worth knowing about before evaluating any vial from any supplier:

Peptide vs. salt form confusion. Semaglutide is sold in different salt/buffer formulations, and vendors aren't always clear about which one is in the vial. A COA should specify this, not just give a generic "semaglutide" label.

Mass spec, not just HPLC. Same issue as with BPC-157/TB-500 — HPLC purity alone can't confirm the actual sequence is correct, only that whatever's in there is chemically "clean" at some purity percentage. A vendor should be able to produce a COA with mass spec confirming the molecule matches semaglutide's actual mass.

Batch-to-COA traceability. The COA needs a batch/lot number that matches what's printed on the vial you actually receive. A COA that can't be tied to your specific vial isn't verifying anything about what you have in hand.

Storage claims. Watch for vendors claiming extended room-temperature stability beyond what's generally supported — that's a common area where marketing outruns the data.

I'm intentionally not getting into use/administration in this post — that's outside what's appropriate for me to weigh in on here, and it's a separate question from vial quality anyway.

We keep a page with more detail on what to check on a semaglutide COA specifically, if useful: https://peptideatlasx.com/semaglutide-10mg-vial/

Curious what others here have seen in terms of COA quality from different vendors — always good to compare notes.