HGH promotion

I've been curious about Tesamorelin vs Semorelin too. From what I've seen, Tesamorelin seems more focused on reducing visceral fat in HIV patients, while Semorelin is more of a general stimulator for natural HGH release. Mechanistically, both act on GHRH receptors but Tesamorelin is a bit more selective? Not sure if anyone's compared their immune or inflammatory effects though, that could be an interesting angle.

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Anyone else feel like lots of the HGH promo stuff ignores actual peptide nuances? Like, the way some peptides influence HGH release or mimic its effects can be way more subtle than just “boosting” levels.

I’m kinda stuck wondering how much of the observed benefits come from downstream IGF-1 stuff versus direct receptor action. And, honestly, it’s weird how little solid placebo-controlled data there is on many of the peptides in this space.

Does anyone know of some newer studies that break down these mechanisms better? Or is it mostly just anecdotal at this point?